1225549-98-3Relevant academic research and scientific papers
Non-natural nucleosides based on 1,2,4-triazolo[1,5-a]pyrimidin-7-ones
Chupakhin, Oleg N.,Shestakova, Tatiana S.,Deev, Sergey L.,Eltsov, Oleg S.,Rusinov, Vladimir L.
experimental part, p. 1149 - 1163 (2010/10/04)
Two methods for synthesis of new nucleosides bearing 6-phenyl-l,2,4- triazolo[l,5-a]pyrimidin-7-ones as a base have been developed. The first one includes Vorbrggen glycosylation reaction. The second method, which is effective for synthesis of acyclic nucleosides, is based on the condensation between sodium salts of 6-phenyl-1,2,4-triazolo [1,5-a]pyrimidin-7-ones and 4-bromobuthyl acetate or (Z)-4-bromobut-2-en-1-yl acetate.
1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors
Deev,Yasko,Karpenko,Korovina,Khandazhinskaya,Andronova,Galegov,Shestakova,Ulomskii,Rusinov,Chupakhin,Kukhanova
experimental part, p. 265 - 270 (2011/02/22)
A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2, 4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antih
