1225638-58-3Relevant academic research and scientific papers
A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas
Smith, Keith,El-Hiti, Gamal A.,Hegazy, Amany S.,Kariuki, Benson
, p. 1219 - 1227 (2011)
Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.
One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N′-benzyl-N,N-dimethylureas
Smith, Keith,El-Hiti, Gamal A.,Hegazy, Amany S.
supporting information; experimental part, p. 2790 - 2792 (2010/09/04)
Lithiation of various N′-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 °C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.
