1226-05-7Relevant academic research and scientific papers
Divergent synthesis of flavones and aurones via base-controlled regioselective palladium catalyzed carbonylative cyclization
Xu, Shan,Sun, Huaming,Zhuang, Mengyuan,Zheng, Shaohua,Jian, Yajun,Zhang, Weiqiang,Gao, Ziwei
, p. 264 - 270 (2018)
A regioselective approach for construction of 5-membered and 6-membered flavonoid is established by Pd catalyzed carbonylative cyclization of 2-iodophenol with terminal alkynes using different amine bases under mild reaction condition. The catalytic experiments found that piperazine preferentially accelerate 6-endo cyclization, and triethylamine mediated Pd catalyzed 5-exo cyclization. Under optimized reaction condition, Pd catalyzed carbonylative protocol successfully applied for the diverse structures of 39 examples in good to excellent yield and regioselectivity.
The five carbonyl iron as CO release source preparation benzopyranone compounds (by machine translation)
-
Paragraph 0014; 0059-0062, (2017/07/06)
The invention discloses a five-carbonyl iron as CO release source preparation benzopyranone compound of the method, the method to acetic acid palladium are the catalyst, piperazine is alkali, five carbonyl iron as CO release source, so that the 2 - iodo phenol compound with a terminal alkyne under mild condition coupled reactions, generating benzopyranone compounds. The invention has simple operation, mild reaction conditions, less catalyst levels, low source amount used CO release, toxicity is relatively small, low cost, wide applicability of the substrate, the target substance high yield, natural product can be widely used for the preparation of the benzopyranone compound. (by machine translation)
