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1226-09-1

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1226-09-1 Usage

General Description

1-(5-CHLORO-2-HYDROXYPHENYL)-3-(4-METHOXYPHENYL)PROP-2-EN-1-ONE, also known as curcumin, is a chemical compound that is naturally found in the spice turmeric. It is known for its bright yellow color and is used as a food coloring and flavoring agent. Curcumin has also been studied for its potential health benefits, including its anti-inflammatory and antioxidant properties. It has been used in traditional medicine for centuries and is the subject of ongoing research for its potential as a therapeutic agent in various diseases and conditions. Additionally, curcumin has been investigated for its potential use in cosmetics and skincare products due to its antioxidant and anti-inflammatory properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1226-09-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1226-09:
(6*1)+(5*2)+(4*2)+(3*6)+(2*0)+(1*9)=51
51 % 10 = 1
So 1226-09-1 is a valid CAS Registry Number.

1226-09-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(5-chloro-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

1.2 Other means of identification

Product number -
Other names 2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(4-methoxyphenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1226-09-1 SDS

1226-09-1Relevant articles and documents

Iodine-mediated direct synthesis of 3-iodoflavones

Patil, Avinash M.,Kamble, Dayanand A.,Lokhande, Pradeep D.

, p. 1299 - 1307 (2018/04/05)

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

Design and synthesis of chalcone derivatives as potent tyrosinase inhibitors and their structural activity relationship

Akhtar, Muhammad Nadeem,Sakeh, Nurshafika M.,Zareen, Seema,Gul, Sana,Lo, Kong Mun,Ul-Haq, Zaheer,Shah, Syed Adnan Ali,Ahmad, Syahida

, p. 97 - 103 (2015/03/04)

Browning of fruits and vegetables is a serious issue in the food industry, as it damages the organoleptic properties of the final products. Overproduction of melanin causes aesthetic problems such as melisma, freckles and lentigo. In this study, a series of chalcones (1-10) have been synthesized and examined for their tryrosinase inhibitory activity. The results showed that flavokawain B (1), flavokawain A (2) and compound 3 were found to be potential tyrosinase inhibitors, indicating IC50 14.20-14.38 μM values. This demonstrates that 4-substituted phenolic compound especially at ring A exhibited significant tyrosinase inhibition. Additionally, molecular docking results showed a strong binding affinity for compounds 1-3 through chelation between copper metal and ligands. The detailed molecular docking and SARs studies correlate well with the tyrosinase inhibition studies in vitro. The structures of these compounds were elucidated by the 1D and 2D NMR spectroscopy, mass spectrometry and single X-ray crystallographic techniques. These findings could lead to design and discover of new tyrosinase inhibitors to control the melanine overproduction and overcome the economic loss of food industry.

Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

Wang, Fang-Wu,Wang, Sheng-Qing,Zhao, Bao-Xiang,Miao, Jun-Ying

, p. 3062 - 3070 (2014/05/06)

A series of 2′-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2-7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.

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