1226-56-8Relevant articles and documents
Flavonoid compound as well as preparation method, preparation and application thereof
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Paragraph 0035, (2017/08/31)
The invention discloses a flavonoid compound as well as a preparation method, a preparation and application thereof. A structure of the flavonoid compound is described in the description, wherein X is halogen, and R is other compound residues. The preparation method comprises the following steps: a synthesis general formula of the flavonoid compound is described in the description; and shown chalcone is dissolved in an organic solvent, and stirring reaction is carried out for 0.3-0.8h at the temperature of 130-140 DEG C under the action of a catalyst to obtain the flavonoid compound as a target object. The preparation is prepared by adding a pharmaceutically acceptable adjuvant in the flavonoid compound. The application is application of the flavonoid compound in preparing an anti-tumor drug. The compound provided by the invention is a compound with an entirely new structure, has obvious anti-tumor action and can be used as a potential lead compound.
Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin v inhibitors
Alvim, Joel,Severino, Richele P.,Marques, Emerson F.,Martinelli, Ariane M.,Vieira, Paulo C.,Fernandes, Joao B.,Da Silva, M. Fatima Das G. F.,Correa, Arlene G.
experimental part, p. 687 - 695 (2010/11/18)
Cathepsin V is a papain-like cysteine protease. It is involved in the control of human T cells (responsible for cell immunity), and presents the largest elastolytic activity among the proteolytic enzymes. Therefore, cathepsin V is a potential molecular ta
