1226-56-8Relevant academic research and scientific papers
Flavonoid compound as well as preparation method, preparation and application thereof
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Paragraph 0035, (2017/08/31)
The invention discloses a flavonoid compound as well as a preparation method, a preparation and application thereof. A structure of the flavonoid compound is described in the description, wherein X is halogen, and R is other compound residues. The preparation method comprises the following steps: a synthesis general formula of the flavonoid compound is described in the description; and shown chalcone is dissolved in an organic solvent, and stirring reaction is carried out for 0.3-0.8h at the temperature of 130-140 DEG C under the action of a catalyst to obtain the flavonoid compound as a target object. The preparation is prepared by adding a pharmaceutically acceptable adjuvant in the flavonoid compound. The application is application of the flavonoid compound in preparing an anti-tumor drug. The compound provided by the invention is a compound with an entirely new structure, has obvious anti-tumor action and can be used as a potential lead compound.
Construction of the flavones and aurones through regioselective carbonylative annulation of 2-bromophenols and terminal alkynes
Liu, Jianming,Liu, Muwen,Yue, Yuanyuan,Zhang, Ningfei,Zhang, Yuanli,Zhuo, Kelei
supporting information, p. 1802 - 1807 (2013/04/24)
The easily available and efficient catalyst containing a benzimidazolium ligand and PdCl2(PPh3)2 demonstrated excellent catalytic activity to construct the flavones and aurones, respectively. This reaction can be operated under mild conditions, affording the desired products in moderate to good yields. This protocol was used to prepare the flavones and aurones by a slight modification of amines.
Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin v inhibitors
Alvim, Joel,Severino, Richele P.,Marques, Emerson F.,Martinelli, Ariane M.,Vieira, Paulo C.,Fernandes, Joao B.,Da Silva, M. Fatima Das G. F.,Correa, Arlene G.
experimental part, p. 687 - 695 (2010/11/18)
Cathepsin V is a papain-like cysteine protease. It is involved in the control of human T cells (responsible for cell immunity), and presents the largest elastolytic activity among the proteolytic enzymes. Therefore, cathepsin V is a potential molecular ta
COMPOUNDS FOR IMMUNOPOTENTIATION
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Page/Page column 121, (2010/02/15)
Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
