122620-48-8

Basic information

• Product Name: (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one
• Synonyms: (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one
• CAS NO: 122620-48-8
• Molecular Weight: 407.626
• Mol File: 122620-48-8.mol

Chemical Properties

• CAS DataBase Reference: (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one(122620-48-8)
• EPA Substance Registry System: (3S,4R)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-methoxy-azetidin-2-one(122620-48-8)

Safety Data

• Hazardous Substances Data: 122620-48-8(Hazardous Substances Data)

Upstream product

• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 121534-58-5 (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid methoxy-amide 
• 120378-96-3 (S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-1-methoxy-azetidin-2-one 
• 122553-24-6 C₂₇H₅₁NO₅Si₂ 
• 120378-89-4 (3R,4S)-5-Benzyloxy-3-hydroxy-4-methyl-pentanoic acid ethyl ester 

Downstream Products

• 93711-85-4 (2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid 

Relevant articles and documents

A New Synthetic Route to the Key Precursor of 1β-Methylcarbapenem Antibiotics from (S)-Methyl 3-Hydroxy-2-methylpropanoate

A new synthetic route to the 1β-methylcarbapenem precursor from (S)-methyl 3-hydroxy-2-methylpropanoate has been developed which involves as a key step the chelation-controlled aldol reaction of (S)-3-benzyloxy-2-methylpropanal with ketene trimethylsilyl acetal of ethyl (trimethylsilyl)acetate.

A NOVEL, DOUBLE-ASYMMETRIC ALDOL APPROACH TO THE SYNTHESIS OF A 1β-METHYL CARBAPENEM ANTIBIOTIC PRECURSOR

A novel synthetic approach to the 1β-methyl carbapenem key precursor is described which involves the chelation-controlled double-asymmetric aldol reaction as the key step.