122624-57-1

Basic information

• Product Name: P-(Benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinic acid
• Synonyms: P-(Benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinic acid
• CAS NO: 122624-57-1
• Molecular Weight: 385.397
• Mol File: 122624-57-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: P-(Benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: P-(Benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinic acid(122624-57-1)
• EPA Substance Registry System: P-(Benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinic acid(122624-57-1)

Safety Data

• Hazardous Substances Data: 122624-57-1(Hazardous Substances Data)

Upstream product

• 87438-94-6 ethyl 2-isobutylacrylate 
• 131066-43-8 N-benzyloxycarbonylaminomethyl-H-phosphinic acid 
• 865703-09-9 2-hydroxyphosphinoylmethyl-4-methyl-pentanoic acid ethyl ester 
• 50-00-0 formaldehyd 
• 621-84-1 O-benzyl carbamate 
• 37760-81-9 N,N'-methylenebis(benzylcarbamate) 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 253192-90-4 O-Adamantyl P-(benzyloxycarbonylaminomethyl)-P-(ethyl 2-isobutylpropionate-3-yl)phosphinate 
• 253192-91-5 2-[(adamantan-1-yloxy)-(benzyloxycarbonylamino-methyl)-phosphinoylmethyl]-4-methyl-pentanoic acid 

Relevant articles and documents

Phosphinic peptide matrix metalloproteinase-9 inhibitors by solid-phase synthesis using a building block approach

The solid-phase synthesis of an array of different pseudopeptides containing a phosphinic glycine-leucine moiety (-GΨ{P(O)OH-CH2}L-)[1] is described. The resulting pseudopeptides were shown to act as matrix metalloproteinase-9 (MMP-9

Synthesis of phosphorus isosters of β-amyloid peptides fragments

We have developed a synthetic route to pseudo dipeptides, analogs of certain fragments of β-amyloid peptides (products of the APP protein hydrolysis). These compounds can be used for preparation of phosphinic acidic oligopeptides representing the peptide sequence of the β-amyloid but containing the phosphorus isoster peptide fragment. Synthesis of pseudo ornityl-glutamate, pseudo arginyl-glutamate, pseudo glycyl-leucine, and pseudo isoleucyl-glycine via amino- and amidoalkylation of phosphonic acids containing the structural isoster of the corresponding amino acid is described.