1226516-00-2Relevant articles and documents
Dolabellane-type diterpenoids with antiprotozoan activity from a southwestern caribbean gorgonian octocoral of the genus Eunicea
Wei, Xiaomei,Rodriguez, Abimael D.,Baran, Peter,Raptis, Raphael G.
experimental part, p. 925 - 934 (2010/09/09)
Ten new diterpenes, 1-10, having a dolabellane skeleton were isolated from a Colombian gorgonian coral of the genus Eunicea. Their structures, as well as those of known compounds 11-18, were determined on the basis of spectroscopic analysis and, in some instances, by chemical conversion and X-ray crystallographic analysis. The absolute structure of 7 was established by chemical conversion from 11, a co-occurring dolabellane congener of known absolute structure. Most of these diterpenoids showed antimalarial activity against the protozoan parasite Plasmodium falciparum.