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Usage

Uses

Used in Pharmaceutical Industry:
(E)-diphenyl-β-(trifluoromethyl)vinylsulfonium trifluoromethanesulfonate is used as a synthetic reagent for the introduction of a trifluoromethyl group into molecules, which is essential in the development of various pharmaceuticals. The trifluoromethyl group often enhances the pharmacological properties of the resulting compounds, making this reagent a valuable tool in drug discovery and design.
Used in Agricultural Industry:
In the agricultural sector, (E)-diphenyl-β-(trifluoromethyl)vinylsulfonium trifluoromethanesulfonate is used as a reagent to introduce a trifluoromethyl group into agrochemicals, potentially improving their effectiveness and selectivity as pesticides or herbicides.
Used in Materials Science:
(E)-diphenyl-β-(trifluoromethyl)vinylsulfonium trifluoromethanesulfonate is also utilized in materials science as a reagent to incorporate a trifluoromethyl group into polymers and other materials. This modification can enhance the material's properties, such as stability, durability, and chemical resistance, making it suitable for various applications, including coatings, adhesives, and advanced materials.
Safety Precaution:
It is important to handle (E)-diphenyl-β-(trifluoromethyl)vinylsulfonium trifluoromethanesulfonate with care, as it may pose risks to health and the environment. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be followed during its use and storage.

Upstream product

• 1228046-56-7 (β-trifluoromethyl)vinyl diphenylsulfonium trifluoromethanesulfonate 
• 66003-76-7 Diphenyliodonium triflate 
• 155444-61-4 phenyl β-(trifluoromethyl)vinyl sulfide 
• 102687-66-1 phenyl (E)-β-(trifluoromethyl)vinyl sulfide 
• 108-98-5 thiophenol 

Downstream Products

• 1330062-96-8 C₁₄H₁₂F₃NO₅ 
• 1330062-68-4 C₂₀H₁₇F₃O₄ 
• 1330062-95-7 C₁₄H₁₃F₃O₃ 
• 1330062-98-0 C₁₄H₁₂BrF₃O₃ 

Relevant academic research and scientific papers

Annulation of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts: Synthesis of dihydrofuran derivatives

A new synthetic approach to dihydrofuran derivatives via the annulation reaction of β-naphthols and 4-hydroxycoumarins with vinylsulfonium salts has been developed. A variety of dihydrofuran derivatives were prepared in moderate to good yields under mild conditions. The products could be readily transformed to the corresponding furans via the dehydrogenation with DDQ.

A practical synthesis and applications of (E)-diphenyl-β- (trifluoromethyl)vinylsulfonium triflate

(E)-Diphenyl-β-(trifluoromethyl)vinylsulfonium triflate, readily prepared from 2-bromo-3,3,3-trifluoroprop-1-ene in two steps, undergoes double alkylation with active methylene compounds in dimethyl sulfoxide or ethyl acetate, in an open vessel at room te

β-(trifluoromethyl)vinyl sulfonium salts: Preparation and reactions with active methylene and methenyl compounds

Two trifluoromethyl-substituted building blocks β-(trifluoromethyl) vinyl sulfonium salts 1 and 2 were developed. Reactions of β- (trifluoromethyl)vinyl sulfonium salt 1 with active methylene compounds containing electron-withdrawing groups using DBU as the base in DMSO occurred to give trifluoromethyl-substituted cyclopropane derivatives 7 as the major products. In contrast, reactions of β-(trifluoromethyl)vinyl sulfonium salt 2 with active methylene compounds occurred with the migration of one of the electron-withdrawing groups to give the products 8 as the major products when NaH was used as the base in DMSO. Moreover, when NaH was used as base in THF/CH2Cl2 at -78 °C, reaction of β- (trifluoromethyl)vinyl sulfonium salt 1 gave trifluoromethyl-substituted 2,3-dihydrofuran derivatives 9 as the major products. A working mechanism was proposed to explain the different behaviors of the β-(trifluoromethyl)vinyl sulfonium salts 1 or 2 with active methylene compounds under these different conditions.