122661-93-2

Basic information

• Product Name: 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester
• CAS NO: 122661-93-2
• Molecular Weight: 434.519
• Mol File: 122661-93-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester(122661-93-2)
• EPA Substance Registry System: 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester(122661-93-2)

Safety Data

• Hazardous Substances Data: 122661-93-2(Hazardous Substances Data)

Upstream product

• 85573-73-5 2β-chloromethyl-2α-methylpenicillin-3α-carboxylic acid diphenylmethyl ester 
• 288-36-8 1,2,3-triazole 
• 205320-23-6 benzhydryl-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4-oxide 
• 80353-26-0 6α-bromopenicillan-3α-carboxylic acid diphenylmethyl ester-1β-oxide 
• 87579-78-0 diphenylmethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide 
• 74189-25-6 diphenylmethyl 6α-bromopenicillanate 
• 551-16-6 6-Aminopenicillanic Acid 
• 24138-28-1 6-bromopenicillanic acid 
• 85573-72-4 (R)-2-[2-(benzothiazol-2-yldisulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyl-3-enoic acid benzhydryl ester 

Downstream Products

• 89786-04-9 tazobactam 

Relevant articles and documents

A new approach to the synthesis of tazobactam using an organosilver compound

Tazobactam (9) was synthesized in 8 steps from the readily accessible 6-APA. By the first use of silver triazole as reactant, the formation of the isomer 7 was avoided and a total yield of 50%, which was two to three times higher than that of reported procedures for 9, was obtained. Georg Thieme Verlag Stuttgart.

PROCESS FOR THE PREPARATION OF TAZOBACTAM

The present invention relates to an improved process for the preparation of Tazobactam of formula (I) having reduced content of cresol. (Formula I) (I)

Process for preparation of penam derivatives from cepham derivatives

The present invention relates to a process for preparing 2α-methyl-2β-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2β-heterocyclyl methyl penam derivatives of the formula (I) wherein R1 represents carboxylic acid protecting group; R2 and R3 may be same or different and independently represent hydrogen, halogen, NH2, acylamino, phthalimido with a proviso that both R2 and R3 are not NH2, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.