122665-96-7 Usage
Uses
Used in Pharmaceutical Research:
3-Fluorocyclobutanecarboxylic acid is utilized as an intermediate in the synthesis of various biologically active molecules, contributing to the development of novel drugs and therapeutic agents. Its unique chemical structure and potential pharmacological properties make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Fluorocyclobutanecarboxylic acid serves as a key building block for the preparation of various pharmaceutical compounds. Its versatility in chemical reactions allows for the creation of a wide range of molecules with potential applications in medicine and other industries.
Used in Medicinal Chemistry:
3-Fluorocyclobutanecarboxylic acid is employed in medicinal chemistry for the design and synthesis of pharmaceutical compounds. Its unique properties and reactivity enable the development of new molecules with improved therapeutic effects and reduced side effects, enhancing the overall efficacy of drug treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 122665-96-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,6,6 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 122665-96:
(8*1)+(7*2)+(6*2)+(5*6)+(4*6)+(3*5)+(2*9)+(1*6)=127
127 % 10 = 7
So 122665-96-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H7FO2/c6-4-1-3(2-4)5(7)8/h3-4H,1-2H2,(H,7,8)
122665-96-7Relevant academic research and scientific papers
Kinetic and thermodynamic effects in the thermal electrocyclic ring-openings of 3-fluorocyclobutene, 3,3-difluorocyclobutene, and 3-(trifluoromethyl)cyclobutene
Dolbier,Gray,Keaffaber,Celewicz,Koronia k
, p. 363 - 367 (2007/10/02)
The synthesis and thermal electrocyclic ring-opening of 3-fluorocylobutane, 4, 3,3-difluorocyclobutane, 5, and 3-(trifluoromethyl)cyclobutane, 6, are reported. Activation energies for their ring-openings were found to be 28.1, 45.0, and 36.3 kcal/mol, respectively. 6 was found to form both the (E)- and the (Z)-5,5,5-trifluoro-1,3,butadienes, in a 95:5 ratio. Thermal equilibrations of the diene products from 4 and 6 were also carried out. The results demonstrate that a CF3 group exhibits only a slight preference for outward rotation (ΔE(a) = 1.2 kcal/mol), while a fluorine substituent gives rise to a much more dramatic outward rotational preference (ΔE(a) = 13.8 kcal/mol). These results were consistent with those previously reported for perfluorinated systems and with theoretical expectations.
