122673-69-2

Upstream product

• 3111-52-2 potassium thiophenolate 
• 108-98-5 thiophenol 
• 4042-35-7 (S)-4-methyloxazolidin-2-one 
• 261729-79-7 (R)-N-benzyloxycarbonyl-1-methyl-2-phenylsulfanylethylamine 
• 131830-48-3 (R)-2,4-dimethyl-2-oxazoline 

Downstream Products

• 155769-02-1 2-chloro-N-[(R)-1-phenylthio-2-propyl]adenosine 
• 261729-98-0 N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1S)-1-phenylethyl]formamide 
• 261729-99-1 N-[(1R)-1-methyl-2-(phenylsulfinyl)ethyl]-N-[(1R)-1-phenylethyl]formamide 
• 261730-13-6 (1R,3R)-1,3-dimethyl-4-(phenylsulfanyl)-1,2,3,4-tetrahydroisoquinoline-2-carbaldehyde 
• 261730-12-5 (1S,3R)-2-formyl-1,3-dimethyl-4-phenylsulfanyl-1,2,3,4-tetrahydroisoquinoline 
• 261729-85-5 N-benzyl-N-[(R)-1-methyl-2-phenylsulfinylethyl]formamide 
• 261730-06-7 (R)-2-formyl-3-methyl-4-phenylsulfanyl-1,2,3,4-tetrahydroisoquinoline 
• 261729-94-6 N-[(R)-1-methyl-2-phenylsulfanylethyl]-N-[(S)-1-phenylethyl]formamide 
• 261729-95-7 N-[(R)-1-methyl-2-phenylsulfanylethyl]-N-[(R)-1-phenylethyl]formamide 
• 261729-83-3 N-benzyl-N-[(R)-1-methyl-2-phenylsulfanylethyl]formamide 
• 261729-81-1 (R)-N-benzyl-1-methyl-2-phenylsulfanyl-ethylamine 
• 261729-90-2 (1R)-1-methyl-N-[(S)-1-phenylethyl]-2-phenylsulfanylethylamine 
• 261729-91-3 (1R)-1-methyl-N-[(R)-1-phenylethyl]-2-phenylsulfanylethylamine 

Relevant academic research and scientific papers

Base-promoted aminoethylation of thiols with 2-oxazolidinones: A simple synthesis of 2-aminoethyl sulfides

A simple synthesis of 2-aminoethyl sulfides using a base-promoted reaction of 2-oxazolidinones with thiols is described. An application of this method to the synthesis of chiral 2-aminoethyl sulfides and sulfur-containing heterocyclic compounds is also presented.

HPLC-based method for determination of absolute configuration of α-chiral amines

We introduce a novel, HPLC-based method for facile determination of the absolute configuration of α-chiral amines. Our method is easily applied to a variety of compounds, including amino acid derivatives. The method involves initial derivatization of the

A Chiral Synthesis of Four Stereoisomers of 1,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline, an Inducer of Parkinson-like Syndrome

Four stereoisomers of 1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline, an inducer of Parkinson-like syndrome, were synthesized by applying a new method of 1,2,3,4-tetrahydroisoquinoline (TIQ) synthesis utilizing the Pummerer reaction as a key step. The chiral centers at C-1 and C-3 were constructed by two routes starting from alaninol (3) and 1-phenylethylamine (4) as a chiral source. Enantiomerically pure 1,3-dimethyl-TIQs (1R,3S)-(1), (1S,3R)-(ent-1), (1S,3S)-(2), and (1R,3R)-(ent-2) were prepared in a stereochemically unambiguous manner from 3 in 11 steps (route I) and from 4 in 6 steps (route II). The conformations of tetrahydroisoquinoline ring in 1-methyl, 3-methyl, and 1,3-dimethyl-TIQs were discussed on the basis of their CD, 1H-NMR spectra, and steric energies.