1226773-47-2Relevant academic research and scientific papers
HETEROARYL RHEB INHIBITORS AND USES THEREOF
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Page/Page column 291, (2018/11/10)
The present invention provides compounds, compositions thereof, and methods of using the same. Compositions comprising a compound of this invention or a pharmaceutically acceptable derivative thereof and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The amount of the compound in compositions of this invention is such that it is effective to measurably inhibit Rheb, in a biological sample or in a patient.
Discovery of novel benzoxaborole-based potent antitrypanosomal agents
Ding, Dazhong,Zhao, Yaxue,Meng, Qingqing,Xie, Dongsheng,Nare, Bakela,Chen, Daitao,Bacchi, Cyrus J.,Yarlett, Nigel,Zhang, Yong-Kang,Hernandez, Vincent,Xia, Yi,Freund, Yvonne,Abdulla, Maha,Ang, Kean-Hooi,Ratnam, Joseline,McKerrow, James H.,Jacobs, Robert T.,Zhou, Huchen,Plattner, Jacob J.
scheme or table, p. 165 - 169 (2010/10/21)
We report the discovery of benzoxaborole antitrypanosomal agents and their structure?activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC5
