1226795-81-8Relevant articles and documents
Discovery of a new series of Aurora inhibitors through truncation of GSK1070916
Medina, Jesus R.,Grant, Seth W.,Axten, Jeffrey M.,Miller, William H.,Donatelli, Carla A.,Hardwicke, Mary Ann,Oleykowski, Catherine A.,Liao, Qiaoyin,Plant, Ramona,Xiang, Hong
scheme or table, p. 2552 - 2555 (2010/07/05)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, dependi