1226795-87-4Relevant academic research and scientific papers
Discovery of a new series of Aurora inhibitors through truncation of GSK1070916
Medina, Jesus R.,Grant, Seth W.,Axten, Jeffrey M.,Miller, William H.,Donatelli, Carla A.,Hardwicke, Mary Ann,Oleykowski, Catherine A.,Liao, Qiaoyin,Plant, Ramona,Xiang, Hong
, p. 2552 - 2555 (2010)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, dependi
