122684-54-2

Basic information

• Product Name: (5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane
• Synonyms: (5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane;5-Chloro-3-cyclopropyl-1,2,4-thiadiazole
• CAS NO: 122684-54-2
• Molecular Formula: C₅H₅ClN₂S
• Molecular Weight: 160.6246
• Mol File: 122684-54-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane(122684-54-2)
• EPA Substance Registry System: (5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane(122684-54-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 122684-54-2(Hazardous Substances Data)

Usage

Description

(5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane, also known as CCTP, is a chemical compound with the molecular formula C5H4ClN2S. It is a cyclopropyl-thiadiazole derivative that is used as a potent and selective antagonist for the metabotropic glutamate receptor subtype 1 (mGluR1). CCTP has been studied for its potential therapeutic applications in neurological disorders such as chronic pain, epilepsy, and neurodegenerative diseases. Its unique structure and pharmacological activity make it a promising candidate for the development of new drugs targeting mGluR1, and further research is ongoing to explore its potential in treating various neurological conditions.

Uses

Used in Pharmaceutical Industry:
(5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane is used as a therapeutic agent for the treatment of neurological disorders such as chronic pain, epilepsy, and neurodegenerative diseases. Its potent and selective antagonism of the metabotropic glutamate receptor subtype 1 (mGluR1) makes it a promising candidate for the development of new drugs targeting this receptor.
Used in Research and Development:
(5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane is used as a research tool for studying the role of mGluR1 in neurological disorders and for the development of new drugs targeting this receptor. Its unique structure and pharmacological activity provide valuable insights into the mechanisms underlying these conditions and contribute to the advancement of therapeutic strategies.
Used in Drug Design and Synthesis:
(5-Chloro-1,2,4-thiadiazol-3-yl]cyclopropane serves as a structural template for the design and synthesis of new drugs targeting mGluR1. Its potent and selective antagonistic activity against this receptor makes it an attractive starting point for the development of novel therapeutic agents for the treatment of neurological disorders.

Relevant articles and documents

1,2,4- THIADIAZOL-5-THIO COMPOUNDS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF AS UREASE AND NITRIFICATION INHIBITORS

The invention relates to methods for the production and use of novel 1,2,4-thiadiazols of general formulae (I) or (II) as agents for regulating the inhibition of enzymatic urea hydrolysis, wherein R1 = hydrogen, C1-C8-alkyl or C6-C10-aryl and R2 = hydrogen, C1-C8- alkyl/heteroalkyl, C2-C8 -alkenyl/heteroalkenyl, C2-C8 -alkinyl/heteroalkinyl, C3-C8- cycloalkyl/heterocycloalkyl, C3-C8 -cycloalkenyl/heterocycloalkenyl, C6-C10 -aryl/heteroaryl, aralkyl, heteroarylalkyl, alkaryl, akheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, hetaroyl, acyloxy, aroyloxy, hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, amino, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, fluorine, chlorine, bromine, iodine, hydroxy, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, the radicals R1 and/or R2 can, optionally, be per se and individually substituted by one or several of the above-mentioned groups. With a limited spectrum of substituents in R2, said compounds can be claimed as nitrification inhibitors. The inventive 1,2,4-thiadiazols thus used are effective urease inhibitors and have a good resistance to hydrolysis and can be produced according to known methods. They are also effective nitrification inhibitors and can delay transformation of ammonia. They are the first inhibitors which effectively eliminate the two main sources of loss during the application of manure, i.e. urease-catalyzed urea hydrolysis and nitrification of ammonia nitrogen. The inventive compounds can also be combined with more potent nitrification inhibitors, whereby nitrogen losses can also be reduced, without any problem.