1226857-47-1

Basic information

• Product Name: (2'‐fluoro[1,1'‐biphenyl]‐2‐yl)acetic acid
• Synonyms: (2'‐fluoro[1,1'‐biphenyl]‐2‐yl)acetic acid
• CAS NO: 1226857-47-1
• Molecular Weight: 230.239
• Mol File: 1226857-47-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2'‐fluoro[1,1'‐biphenyl]‐2‐yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2'‐fluoro[1,1'‐biphenyl]‐2‐yl)acetic acid(1226857-47-1)
• EPA Substance Registry System: (2'‐fluoro[1,1'‐biphenyl]‐2‐yl)acetic acid(1226857-47-1)

Safety Data

• Hazardous Substances Data: 1226857-47-1(Hazardous Substances Data)

Upstream product

• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 

Relevant articles and documents

Identification of 2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide as a Sodium Valproate-like broad spectrum anti-epileptic drug candidate

By further optimizing compound A [2′-fluoro-N-methyl-[1,1′-biphenyl]-2-sulfonamide], we identified DSP-0565 [2-(2′-fluoro-[1,1′-biphenyl]-2-yl)acetamide, 17a] as a strong, broad-spectrum anti-epileptic drug (AED) candidate. Our efforts mainly focused on finding an alternative polar group for the sulfonamide in order to improve ADME profile of compound A including good metabolic stability and no reactive metabolic production. This led to the identification of biphenyl acetamide as a new scaffold for development of broad-spectrum AED candidates. DSP-0565 showed anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin, and was therefore selected as a clinical candidate.