1226862-50-5Relevant academic research and scientific papers
Organocatalytic enantioselective aza-Michael additions of N-heterocycles to α,β-unsaturated enones
Lv, Jian,Wu, Hao,Wang, Yongmei
, p. 2073 - 2083 (2010)
A procedure for enantioselective organocatalytic conjugate additions of a variety of N-heterocycles to α,β-unsaturated enone systems is presented. The reactions are efficiently catalyzed by salts of 9-amino-9-deoxy-epiquinine (3d). Cyclic, acyclic, and aromatic enones can be used in reactions with 1H-benzotriazole (1a) or 5-phenyltetrazole derivatives 12, providing the Michael addition products in high yields and with good to excellent enantioselectivities.
