1226953-84-9Relevant academic research and scientific papers
alpha-hydroxy pinacol borate compound preparation method
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Paragraph 0037-0038; 0041-0042, (2019/11/21)
The invention discloses an alpha-hydroxy pinacol borate compound preparation method, which comprises: carrying out a reaction on a second mixing reaction system containing an alcohol-based compound, adiboron reagent, an iron catalyst, a ruthenium catalyst
α-C-H borylation of secondary alcohols: Via Ru/Fe relay catalysis: Building a platform for alcoholic C-H/C-O functionalizations
Zhu, Qing,He, Zeyu,Wang, Lu,Hu, Yue,Xia, Chungu,Liu, Chao
supporting information, p. 11884 - 11887 (2019/10/11)
An unprecedented α-C-H borylation of secondary alcohols was successfully achieved and delivered various tertiary α-boryl alcohols via [Ru]/[Fe] relay catalysis. The dehydrogenation catalyst (Ru) and borylation catalyst (Fe) interacted to increase the chemoselectivity. By installing the "platform functional group" Bpin via this α-C-H borylation, several alcoholic α-C-H and C-O bond functionalizations were successfully achieved.
Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans: Via copper(i)-catalysed borylative cyclization of aliphatic ketones
Kubota, Koji,Uesugi, Minami,Osaki, Shun,Ito, Hajime
, p. 5680 - 5683 (2019/06/18)
A new method was developed for synthesizing 2-alkyl-2-boryl-tetrahydrofuran derivatives from aliphatic ketones using a copper(i)/N-heterocyclic carbene complex catalyst. This reaction presumably proceeds through the nucleophilic addition of a borylcopper(i) intermediate to ketone, followed by intramolecular substitution of the resulting alkoxide for the halide leaving group. The new borylation products, 2-alkyl-2-boryl-tetrahydrofuran derivatives with a condensed structure around the C-B bond, cannot be synthesized by other methods.
Copper-catalyzed diboration of ketones: Facile synthesis of tertiary α-Hydroxyboronate esters
McIntosh, Melissa L.,Moore, Cameron M.,Clark, Timothy B.
supporting information; experimental part, p. 1996 - 1999 (2010/07/17)
Figure presented The diboration of ketones with the (ICy)CuOt-Bu catalyst was developed to provide access to tertiary α-hydroxyboronate esters. The (ICy)CuOt-Bu catalyst was generated in situ with (ICy)CuCl and NaOt-Bu to afford a more efficient catalyst than the preformed (ICy)CuOt-Bu. These conditions result in the diboration of various ketones in toluene at 50 °C in 2-22 h. Treatment of the resulting products with silica gel affords the corresponding α-hydroxyboronate esters.
