122697-58-9

Upstream product

• 122697-57-8 N-(p-Tolylsulfonyl)<2.2>(1,3)(1,3)-1-thia-10-aza<2.2>(4,6)(1,3)cyclophan 
• 40933-68-4 5,7-Dimethyl-2,11-dithia<3.3>metacyclophan 
• 40933-70-8 4,6-dimethyl<2,2>metacyclophane 
• 51657-11-5 4,6-bis(bromomethyl)<2.2>metacyclophane 
• 1585-15-5 4,6-bis(chloromethyl)-m-xylene 

Relevant academic research and scientific papers

Chiral Triple-Layered and Condensed Cyclophanes - Synthesis, Structure, Chiroptical Properties

The helical title compounds 1 -5 are obtained using a simple one-step cyclisation reaction with yields reaching or increasing those obtained by application of organometallic methods in phane syntheses.The formation of the triple-layered phanes 1 leads with high selectivity only to the "up-down" isomers with fixed conformation, as shown by X-ray crystallography and by the detection of strong NOEs of the inner hydrogen atoms.For studies on structure-chiroptic relationships a systematic sequenceof helicalphanes with larger arene systems is synthesized.Enrichment of enantiomers is achieved by HPLC on (+)-PTrMA; the kinetics of racemisation and the CD spectra are discussed.