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• 51657-11-5 4,6-bis(bromomethyl)<2.2>metacyclophane 
• 40933-70-8 4,6-dimethyl<2,2>metacyclophane 
• 120697-86-1 N-(p-Tolylsulfonyl)-1-thia-14-aza<2>metacyclo<2>(1,3)-4,5,9,10-tetrahydropyrenophan 

Relevant academic research and scientific papers

Chiral Triple-Layered and Condensed Cyclophanes - Synthesis, Structure, Chiroptical Properties

The helical title compounds 1 -5 are obtained using a simple one-step cyclisation reaction with yields reaching or increasing those obtained by application of organometallic methods in phane syntheses.The formation of the triple-layered phanes 1 leads with high selectivity only to the "up-down" isomers with fixed conformation, as shown by X-ray crystallography and by the detection of strong NOEs of the inner hydrogen atoms.For studies on structure-chiroptic relationships a systematic sequenceof helicalphanes with larger arene systems is synthesized.Enrichment of enantiomers is achieved by HPLC on (+)-PTrMA; the kinetics of racemisation and the CD spectra are discussed.