1226974-60-2Relevant academic research and scientific papers
Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy
Shang, Yaping,Jonnada, Krishna,Yedage, Subhash Laxman,Tu, Hua,Zhang, Xiaofeng,Lou, Xin,Huang, Shijun,Su, Weiping
supporting information, p. 9547 - 9550 (2019/08/15)
Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.
One-pot synthesis of arylated 1-methyl-1H-indoles by Suzuki-Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H-indole
Ibad, Muhammad Farooq,Zinad, Dhafer Saber,Hussain, Munawar,Ali, Asad,Villinger, Alexander,Langer, Peter
, p. 7492 - 7504 (2013/08/23)
Arylated 1-methyl-1H-indoles were prepared by Suzuki-Miyaura cross-coupling reactions of 2,3-dibromo-1-methyl-1H-indole and 2,3,6-tribromo-1-methyl-1H- indole. The reactions proceed with very good regioselectivity in favour of position 2.
One-pot synthesis of unsymmetrical 2,3-diarylindoles by site-selective suzuki-miyaura reactions of N -methyl-2,3-dibromoindole
Ibad, Muhammad Farooq,Hussain, Munawar,Abid, Obaid-Ur-Rahman,Ali, Asad,Ullah, Ihsan,Zinad, Dhafer Saber,Langer, Peter
experimental part, p. 411 - 414 (2010/04/06)
The Suzuki-Miyaura reaction of N-methyl-2,3-dibromoindole with two equivalents of boronic acids gave symmetrical 2,3-diarylindoles. The reaction with one equivalent of arylboronic acid resulted in site-selective formation of 2-aryl-3-bromoindoles. The one
