1226976-45-9Relevant academic research and scientific papers
Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs
McNulty, James,Nair, Jerald J.,Singh, Mohini,Crankshaw, Denis J.,Holloway, Alison C.
scheme or table, p. 2335 - 2339 (2010/08/20)
seco-Derivatives of the anticancer agent pancratistatin bearing the 2S,3S,4S,5S configuration were accessed via a novel, highly diastereoselective anti-aldol reaction. Structure-activity relationships reveal important insights into the seco-pancratistatin pharmacophore as a potent and selective inhibitor of human cytochrome P450 3A4 (CYP3A4), and highlight features of concern in advancing a potent, selective anticancer agent in the pancratistatin series.
