1226977-53-2Relevant academic research and scientific papers
Iodoacetic acid is an efficient reagent for the synthesis of amino acid derived 2-aminobenzimidazoles
Krasikovs, Andrejs,Ozola, Vita,Dax, Scott L.,Suna, Edgars
, p. 683 - 693 (2013)
Chiral, nonracemic, N-unprotected amino acids were converted into the corresponding N-benzimidazol-2-yl derivatives by a sequential procedure involving initial formation of isothiocyanates, their reaction with arene-1,2-diamines, and cyclization-desulfurization of the intermediate thioureas with iodoacetic acid. The simplified workup and the lack of volatile or toxic byproducts in the key desulfurization step renders iodoacetic acid a superior reagent to the usual reagent, iodomethane. Georg Thieme Verlag Stuttgart · New York.
