1226977-92-9Relevant academic research and scientific papers
Facile assembly of fused isoquinolines by gold(i)-catalyzed coupling-cyclization reactions between o-alkynylbenzaldehydes and aromatic amines containing tethered nucleophiles
Patil, Nitin T.,Mutyala, Anil Kumar,Pediredla, G. V. V. Lakshmi,Penmatcha, V. K. Raju,Balasubramanian, Sridhar
supporting information; experimental part, p. 1999 - 2007 (2010/06/15)
A gold(I)-catalyzed, operationally simple coupling-cyclization technique was developed for the synthesis of isoquinoline-fused polycyclic compounds. The reaction makes use of two coupling partners such as o-alkynylbenzaldehydes and aromatic amines having tethered nucleophiles. The reaction is easy to perform, broad in scope, and allows the generation of a number of biologically important heterocyclic motifs from readily accessible starting materials. A mechanism for the reaction is discussed.
