1227062-24-9

Upstream product

• 874291-00-6 1-ethyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea 
• 1227062-15-8 C₉H₁₀Cl₂N₄O 

Downstream Products

• 1227061-49-5 1-ethyl-3-[4-[1-(2-hydroxy-2-methyl-propyl)-6-morpholino-pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]urea 

Relevant academic research and scientific papers

mTOR SELECTIVE KINASE INHIBITORS

The 4-urea-phenyl substituted 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine derivatives are potent and selective inhibitors of mTOR kinase and are useful in treating disorders related to abnormal mTOR activities such as cancer, immune disorders, cardiovascular disease, ocular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.

PI3K/MTOR KINASE INHIBITORS

6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H- pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mT0R activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.