1227077-47-5Relevant articles and documents
Titanium(IV) isopropoxide mediated synthesis of pyrimidin-4-ones
Ramanjulu, Joshi M.,Demartino, Michael P.,Lan, Yunfeng,Marquis, Robert
supporting information; experimental part, p. 2270 - 2273 (2010/07/17)
A novel, one-step method for the synthesis of tri- and tetrasubstituted pyrimidin-4-ones is reported. This method involves a titanium(IV)-mediated cyclization involving two sequential condensations of primary and β-ketoamides. The reaction is operationally facile, readily scalable, and offers rapid entry into differentially substituted pyrimidin-4-one scaffolds. The high functional group compatibility allows for substantial diversification in the products generated from this transformation.