1227151-50-9Relevant academic research and scientific papers
Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors
Donnell, Andrew F.,Dollings, Paul J.,Butera, John A.,Dietrich, Arlene J.,Lipinski, Kerri K.,Ghavami, Afshin,Hirst, Warren D.
scheme or table, p. 2163 - 2167 (2010/07/05)
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype.
