1227153-93-6

Basic information

• Product Name: (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-3-hydroxy-4-methyl-2,6,10-triethyl-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone
• Synonyms: (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-3-hydroxy-4-methyl-2,6,10-triethyl-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone
• CAS NO: 1227153-93-6
• Molecular Weight: 501.664
• Mol File: 1227153-93-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-3-hydroxy-4-methyl-2,6,10-triethyl-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-3-hydroxy-4-methyl-2,6,10-triethyl-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone(1227153-93-6)
• EPA Substance Registry System: (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-3-hydroxy-4-methyl-2,6,10-triethyl-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone(1227153-93-6)

Safety Data

• Hazardous Substances Data: 1227153-93-6(Hazardous Substances Data)

Upstream product

• 1243719-00-7 (4R,5S)-3-[(2S,3S,4S,6S,7S,10S,11S)-4-methyl-2,6,10-triethyl-3-triethylsiloxy-6,7;10,11-diepoxydodecanoyl]-4-methyl-5-phenyl-2-oxazolidinone 

Relevant articles and documents

Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A

Recently, we reported that the epoxide hydrolase Lsd19, the first enzyme shown to catalyze epoxide-opening cascades, can catalyze the conversion of a putative bisepoxide intermediate to polyether antibiotic lasalocid, which involves energetically disfavored 6-endo-tet cyclization of the epoxy alcohol. Here, we examined the substrate tolerance of Lsd19. Lsd19 accepts various substrate analogues differing in the left segment of lasalocid and epoxide stereochemistry to afford either THF-THP or THF-THF products with excellent regioselectivity.