122722-30-9

Basic information

• Product Name: N-Benzyl-2,2,2-trichloro-N-(1-methyl-allyl)-acetamide
• Synonyms: N-Benzyl-2,2,2-trichloro-N-(1-methyl-allyl)-acetamide
• CAS NO: 122722-30-9
• Molecular Weight: 306.619
• Mol File: 122722-30-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Benzyl-2,2,2-trichloro-N-(1-methyl-allyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2,2,2-trichloro-N-(1-methyl-allyl)-acetamide(122722-30-9)
• EPA Substance Registry System: N-Benzyl-2,2,2-trichloro-N-(1-methyl-allyl)-acetamide(122722-30-9)

Safety Data

• Hazardous Substances Data: 122722-30-9(Hazardous Substances Data)

Upstream product

• 133957-65-0 N-(but-3-en-2-yl)-benzamide 
• 37857-30-0 N-benzyl(but-3-en-2-yl)amine 

Downstream Products

• 122722-37-6 (4S,5S)-1-Benzyl-3,3-dichloro-4-chloromethyl-5-methyl-pyrrolidin-2-one 
• 122722-37-6 trans N-benzyl-3,3-dichloro-4-chloromethyl-5-methyl-pyrrolidin-2-one 

Relevant articles and documents

Transition Metal-Catalyzed Radical Cyclizations: A Low-Temperature Process for the Cyclization of N-Protected N-Allyltrichloroacetamides to Trichlorinated γ-Lactams and Application to the Stereoselective Preparation of β,γ-Disubstituted γ-Lactams

Cyclisations of N-substituted N-allyltrichloroacetamides, where the substituent is an alkyl, Cbz, Boc, Ts, or Ms group, are catalyzed by a 1:1 mixture of CuCl and bipyridine to give the corresponding β,γ-trichlorinated γ-lactams in high yields.The reactions proceed at temperatures from -78 deg C to room temperature.Cyclizations of N-allyltrichloroacetamides of acyclic secondary allylic amines are achieved with good selectivity; the cis/trans ratios of the γ-lactams formed were dependent on the substituents on the nitrogen atom.The stereochemical outcome is compared with that of free-radical cyclization.