1227307-47-2Relevant academic research and scientific papers
Enantioselective Intermolecular Aldehyde Ketone Cross-Coupling through an Enzymatic Carboligation Reaction
Lehwald, Patrizia,Richter, Michael,Mueller, Michael,Roehr, Caroline,Liu, Hung-Wen
experimental part, p. 2389 - 2392 (2010/06/15)
(Figure Presented) Happy new YerE: The first example of the title reaction is presented using a ThDPdependent enzyme catalyst. The substrate tolerance of the enzyme is very broad and includes cyclic and open-chain ketones, as well as diketones and a- and β-ketoesters as acceptor substrates. The absolute configurations of two enzymatic products were determined by single-crystal structure analysis.
