1227366-28-0

Basic information

• Product Name: 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone
• Synonyms: 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone
• CAS NO: 1227366-28-0
• Molecular Weight: 492.41
• Mol File: 1227366-28-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone(1227366-28-0)
• EPA Substance Registry System: 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-hydroxy-2-(4-methoxyphenyl)ethyl]piperidin-1-yl}ethanone(1227366-28-0)

Safety Data

• Hazardous Substances Data: 1227366-28-0(Hazardous Substances Data)

Upstream product

• 1227366-15-5 1-(4-methoxyphenyl)-2-[(2R)-piperidin-2-yl]ethanol 
• 6831-57-8 2-bromo-4,5-dimethoxyphenylacetic acid chloride 

Downstream Products

• 1227366-14-4 2-(2-bromo-4,5-dimethoxyphenyl)-1-{(2R)-2-[2-(4-methoxyphenyl)-2-oxoethyl]piperidin-1-yl}ethanone 

Relevant articles and documents

First asymmetric synthesis of boehmeriasin A

The first asymmetric synthesis of phenanthroquinolizidine alkaloid (R)-boehmeriasin A is described. Two alternative synthetic pathways to the key intermediate (RS,R)-4 were achieved through a combination of highly diastereoselective 1,2-nucleophilic addition on (-)-(S)-l-amino-2-(methoxy methyl)pyrrolidine hydrazones with a ring-closing metathesis to ensure the construction of the piperidine template. A subsequent acylation/oxidation/aldol condensation/radical cyclization sequence completed the assembly of the title (R)configured natural product.