122737-56-8Relevant articles and documents
Oxadiazolyl-azabicyloheptanes for the treatment of senile dementia
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, (2008/06/13)
Oxadiazoles represented by structural formula I: or a salt or prodrug thereof; wherein one of X, Y or Z is an oxygen atom and the other two are nitrogen atoms, and the dotted circle represents aromaticity (two double bonds); R2 represents a substituent of low lipophilicity; the broken line represents an optional chemical bond; and the substituents R3 and R? may be present at any position, including the point of attachment to the oxadiazole ring, and R3 represents halo, C??? alkoxy, carboxy,-NR?R?, C??? alkyl, C?? ? alkyl substituted with hydroxy or C??? alkoxy, or methyl or hydroxy in the 3-, 4-or 5-position; and R? represents hydrogen, halo, C??? alkoxy, hydroxy, carboxy,-NR? R?, C??? alkyl, or C??? alkyl substituted with hydroxy or C??? alkoxy; or R3 and R? together represent carbonyl; and R? and R? independently represent hydrogen or C??? alkyl are potent muscarinic agonists with good CNS penetrability, and are therefore useful in the treatment of neurological and mental illnesses; the compounds are also of benefit in the treatment of severe painful conditions. Processes for preparing these compounds are described, as also are pharmaceutical compositions containing them.
