1227401-27-5 Usage
Description
The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.
references
[1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87.
Check Digit Verification of cas no
The CAS Registry Mumber 1227401-27-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,4,0 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1227401-27:
(9*1)+(8*2)+(7*2)+(6*7)+(5*4)+(4*0)+(3*1)+(2*2)+(1*7)=115
115 % 10 = 5
So 1227401-27-5 is a valid CAS Registry Number.
1227401-27-5Relevant articles and documents
CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
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Page/Page column 12, (2012/02/01)
Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective t
