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7,10-di-troc-N'-Boc-2'-acetyldocetaxel is a semi-synthetic derivative of the potent anti-cancer drug docetaxel. This chemical is characterized by the presence of two trichloroethoxycarbonyl (troc) protecting groups at the 7 and 10 positions, a tert-butoxycarbonyl (Boc) protecting group at the N' position, and an acetyl group at the 2' position. These modifications are designed to protect the functional groups of docetaxel during chemical synthesis, allowing for the introduction of various modifications to improve its pharmacological properties, such as solubility, stability, and bioavailability. The troc and Boc groups are commonly used in organic synthesis as protecting groups, which can be selectively removed under mild conditions to regenerate the parent compound. The acetyl group at the 2' position further modifies the drug's properties, potentially enhancing its therapeutic effects. Overall, 7,10-di-troc-N'-Boc-2'-acetyldocetaxel represents a complex intermediate in the development of novel docetaxel-based anticancer agents.

1227402-71-2

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1227402-71-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1227402-71-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,4,0 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1227402-71:
(9*1)+(8*2)+(7*2)+(6*7)+(5*4)+(4*0)+(3*2)+(2*7)+(1*1)=122
122 % 10 = 2
So 1227402-71-2 is a valid CAS Registry Number.

1227402-71-2Relevant academic research and scientific papers

An efficient semi-synthetic method to construct docetaxel via sterically crowded linear side chain esterification

Shen, Xin,Yang, Jidong,Zhan, Huaxing,Wang, Hu,Wu, Shaohong,Chen, Zili

, p. 31 - 36 (2013)

An efficient semi-synthetic method was developed to construct docetaxel 1 by using N,N-di-Boc protected linear isoserine derivative 5 as the side chain source, in which, bulky protecting group on the nitrogen atom blocked C-2′ position and prohibited unav

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