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(2E,4Z)-5-chloro-1-(2-hydroxy-4,6-dimethoxyphenyl)-5-(3,5-dimethoxyphenyl)penta-2,4-dien-1-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1227403-45-3

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1227403-45-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1227403-45-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,4,0 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1227403-45:
(9*1)+(8*2)+(7*2)+(6*7)+(5*4)+(4*0)+(3*3)+(2*4)+(1*5)=123
123 % 10 = 3
So 1227403-45-3 is a valid CAS Registry Number.

1227403-45-3Downstream Products

1227403-45-3Relevant academic research and scientific papers

Synthesis and biological evaluation of β-chloro vinyl chalcones as inhibitors of TNF-α and IL-6 with antimicrobial activity

Bandgar, Babasaheb P.,Patil, Sachin A.,Korbad, Balaji L.,Nile, Shivraj H.,Khobragade, Chandrahase N.

experimental part, p. 2629 - 2633 (2010/07/09)

A series of β-chloro vinyl chalcones have been synthesized by Claisen-Schmidt condensation. β-chloro vinyl aldehyde has been synthesized by the Vilsmayer-Hack formylation reaction. The structures of the newly synthesized compounds were confirmed by 1H NMR, IR and Mass spectral analysis. All the compounds were evaluated for their anti-inflammatory activity (against TNF-α and IL-6) and antimicrobial (antibacterial and antifungal) activity. Compounds 5a, 5d, 5e, 5g and 5i exhibited promising activity against IL-6 with 58-83% inhibition at 10 μM concentration. None of the compound was found to be cytotoxic in CCK-8 cells at 10 μM concentration. Whereas compounds 5b, 5d, 5e and 5i showed very good antibacterial activity and compounds 5a, 5b, 5e and 5i showed good antifungal activity.

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