1227411-41-7

Basic information

• Product Name: 3-(1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one
• Synonyms: 3-(1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one
• CAS NO: 1227411-41-7
• Molecular Weight: 311.337
• Mol File: 1227411-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one(1227411-41-7)
• EPA Substance Registry System: 3-(1-hydroxy-2-(4-methoxyphenyl)-2-oxoethyl)-3-methylindolin-2-one(1227411-41-7)

Safety Data

• Hazardous Substances Data: 1227411-41-7(Hazardous Substances Data)

Upstream product

• 1504-06-9 3-methylindolin-2-one 
• 1076-95-5 p-methoxyphenylglyoxal 

Relevant articles and documents

Catalytic asymmetric synthesis of 3-(α-hydroxy-ss-carbonyl) oxindoles by a ScIII-catalyzed direct aldol-type reaction

A direct catalytic asymmetric aldol-type reaction of 3-substituted- 2oxindoles with glyoxal derivatives and ethyl trifluoropyruvate, catalyzed by a chiral N,N-'-dioxide-Sc(OTf)3 (Tf=trifluoromethanesulfonyl) complex, has been developed that tolerates a wide range of substrates. The reaction proceeds in good yields and excellent enantioselectivities (up to 93% yield, 99:1 diastereomeric ratio (dr), and > 99 % enantiomeric excess (ee)) under mild conditions, to deliver 3-(α-hydroxy-ss-carbonyl) oxindoles with vicinal quaternary-tertiary or quaternaryquaternary stereocenters. Even with 1 mol% catalyst loading or on scaleup (10 mmol of starting material), maintenance of ee was observed, which showed the potential value of the catalyst system. In studies probing the reaction mechanism, a positive nonlinear effect was observed and ScIII-based enolate intermediates were detected by using ESIMS. On the basis of the experimental results and previous reports, a possible catalytic cycle was assumed.