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1227465-79-3

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1227465-79-3 Usage

General Description

7-fluoro-2-hydroxyquinoline-4-carboxylic acid, also known as SALTDATA: FREE, is a chemical compound with the molecular formula C10H6FNO3. 7-fluoro-2-hydroxyquinoline-4-carboxylic acid(SALTDATA: FREE) is a derivative of quinoline and contains a fluorine atom, a hydroxyl group, and a carboxylic acid moiety. It is often used in pharmaceutical research and drug synthesis due to its potential therapeutic properties. Additionally, SALTDATA: FREE is also used in the manufacturing of agrochemicals and other specialty chemicals. Its unique structure and functional groups make it a versatile building block for various chemical processes and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1227465-79-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,4,6 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1227465-79:
(9*1)+(8*2)+(7*2)+(6*7)+(5*4)+(4*6)+(3*5)+(2*7)+(1*9)=163
163 % 10 = 3
So 1227465-79-3 is a valid CAS Registry Number.

1227465-79-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-fluoro-2-oxo-1H-quinoline-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 7-FLUORO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1227465-79-3 SDS

1227465-79-3Downstream Products

1227465-79-3Relevant articles and documents

Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma

Shahin, Mai I.,Roy, Joyeeta,Hanafi, Maha,Wang, Dongyao,Luesakul, Urarika,Chai, Yifeng,Muangsin, Nongnuj,Lasheen, Deena S.,Abou El Ella, Dalal A.,Abouzid, Khaled A.,Neamati, Nouri

, p. 516 - 530 (2018)

No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines. Some of the active analogues with IC50 values around 10 μM were tested in three additional cell lines. Our structure-activity relationships revealed remarkable alterations in the anti proliferative activities upon modest chemical modifications and autophagy modulation is a suggested mechanism of action.

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