1227475-99-1Relevant academic research and scientific papers
Discovery of sulfonamide-pyrazole γ-secretase inhibitors
Mattson, Matthew N.,Neitzel, Martin L.,Quincy, David A.,Semko, Christopher M.,Garofalo, Albert W.,Keim, Pamela S.,Konradi, Andrei W.,Pleiss, Michael A.,Sham, Hing L.,Brigham, Elizabeth F.,Goldbach, Erich G.,Zhang, Hongbin,Sauer, John-Michael,Basi, Guriqbal S.
, p. 2148 - 2150 (2010)
Utilizing a pharmacophore hypothesis, previously described γ-secretase inhibiting HTS hits were evolved into novel tricyclic sulfonamide-pyrazoles, with high in vitro potency, good brain penetration, low metabolic stability, and high clearance.
