1227489-45-3Relevant academic research and scientific papers
N-Trimethylsilyloxyenamines as new aldehyde enolate synthons: General, efficient and diastereoselective aldol reaction with ketals and acetals
Sonawane, Manoj R.,Cisaova, Ivana,Lyapkalo, Ilya M.
supporting information; experimental part, p. 2656 - 2658 (2010/07/09)
(E)-N-Trimethylsilyloxyenamines, easily accessible from aldonitrones, proved to be excellent nucleophiles in TMSOTf-induced diastereoselective aldol reaction, both with ketals and acetals, proceeding via an extended transition state and leading to a new aldol C-C-bond in the aldonitrone products, that can be readily hydrolysed to the corresponding aldehydes.
