1227502-50-2Relevant articles and documents
Preparation method of 2-aminomethyl-3-chloro-5-tirfluoromethylpyridine hydrochloride
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Paragraph 0019; 0021; 0023, (2017/10/13)
The invention discloses a preparation method of 2-aminomethyl-3-chloro-5-tirfluoromethylpyridine hydrochloride, and belongs to the field of agricultural organic chemical synthesis. The 2-aminomethyl-3-chloro-5-tirfluoromethylpyridine hydrochloride is prepared according to the following steps of using 3-chloro-5-trifluoromethyl-2-pyridinemethanol as a raw material; reacting with phosphorus tribromide to obtain an intermediate of 3-chloro-5-trifluoromethyl-2-bromomethyl pyridine; then, sequentially reacting with hexamethylenetetramine and concentrated hydrochloric acid to obtain the 2-aminomethyl-3-chloro-5-tirfluoromethylpyridine hydrochloride. The preparation method provided by the invention has the following beneficial effects that the raw materials can be easily bought; organic solvents and alkali can be recovered; the yield is relatively high; the product quality is high; the preparation method is a method suitable for being used for preparing the 2-aminomethyl-3-chloro-5-tirfluoromethylpyridine hydrochloride.