1227577-03-8

Basic information

• Product Name: 2-chloro-3-fluoropyridin-4-aMine
• Synonyms: 4-Amino-2-chloro-3-fluoropyridine;2-Chloro-3-fluoro-pyridin-4-ylamine;2-chloro-3-fluoropyridin-4-aMine
• CAS NO: 1227577-03-8
• Molecular Formula: C₅H₄ClFN₂
• Molecular Weight: 146.5500632
• Mol File: 1227577-03-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 271.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.449±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.81±0.42(Predicted)
• CAS DataBase Reference: 2-chloro-3-fluoropyridin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-fluoropyridin-4-aMine(1227577-03-8)
• EPA Substance Registry System: 2-chloro-3-fluoropyridin-4-aMine(1227577-03-8)

Safety Data

• Hazardous Substances Data: 1227577-03-8(Hazardous Substances Data)

Usage

General Description

2-chloro-3-fluoropyridin-4-aMine is a chemical compound that belongs to the class of amines and is also known by its CAS number 890296-25-8. It is a derivative of pyridine and contains both chlorine and fluorine substituents. 2-chloro-3-fluoropyridin-4-aMine is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various organic compounds and pharmaceutical drugs. Its unique structure and properties make it a valuable intermediate in the production of diverse chemical products. Additionally, 2-chloro-3-fluoropyridin-4-aMine has been studied for its potential biological activity and therapeutic applications.

Upstream product

• 1354223-71-4 tert-butyl (2-chloro-3-fluoropyridin-4-yl)carbamate 
• 628691-93-0 2-chloro-3-fluoro-pyridine-4-carboxylic acid 

Downstream Products

• 1365991-97-4 2-chloro-N-(2-chloro-3-fluoro-pyridine-4-yl)-6-fluorobenzamide 
• 1365992-00-2 2,6-dichloro-N-(2-chloro-3-fluoro-pyridin-4-yl)benzamide 
• 1365992-02-4 2,6-dichloro-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-benzamide 
• 1365992-08-0 2,6-dichloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-iodobenzamide 
• 1365992-14-8 2-chloro-N-(2-chloro-4-cyano-6-fluoro-benzoyl)-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-6-fluorobenzamide 
• 1365991-98-5 2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-6-fluorobenzimidoyl chloride 
• 1242249-93-9 4-chloro-2-(2-chloro-6-fluoro-phenyl)-thiazolo[5,4-c]pyridine 
• 1365989-46-3 (2-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-ylamino)pyridin-4-yl)methanol 
• 1365992-01-3 2,6-dichloro-N-(2-chloro-3-fluoropyridin-4-yl)benzimidoyl chloride 
• 1242254-41-6 4-chloro-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine 
• 1365989-47-4 2-[2-(2,6-dichloro-4-cyanophenyl)-thiazolo[5,4-c]pyridine-4-ylamino]-isonicotinonitrile 
• 1365992-03-5 2,6-dichloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-benzimidoyl chloride 
• 1365992-04-6 3,5-dichloro-4-(4-chloro-thiazolo[5,4-c]pyridine-2-yl)-benzonitrile 
• 1365992-05-7 4-(4-bromo-thiazolo[5,4-c]pyridine-2-yl)-3,5-dichloro-benzonitrile 

Relevant articles and documents

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula (I), wherein R1, R3, R4, R5, L1, and Cy are as defined herein. The present invention also provides compounds, methods for the production of said compounds of the invention, pharmaceutical compositions comprising the same and their use in allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 and/or interferons. The present invention also methods for the prevention and/or treatment of the aforementioned diseases by administering a compound of the invention.