122763-01-3Relevant academic research and scientific papers
Cascade Ring-Opening Dual Halogenation of Cyclopropenones with Saturated Oxygen Heterocycles
Gao, Wen-Xia,Huang, Xiao-Bo,Liu, Miao-Chang,Miao, Wei-Hang,Wu, Hua-Yue,Zhou, Yun-Bing
supporting information, p. 9425 - 9430 (2021/12/14)
Represented is a CuX2- or I2-promoted ring-opening dual halogenation of cyclopropenones with saturated oxygen heterocycles, providing an efficient method for the synthesis of 3-haloacrylates. The ring-opening reaction enables the construction of two C–X (X = Cl, Br, or I) bonds and a C–O bond as well as the cleavage of two C–O bonds and a C–C bond in a single step. This protocol is highly atom economical, has an excellent substrate scope, and exhibits the ability for gram-scale reaction.
Monosubstituted 3,3-Difluorocyclopropenes as Bench-Stable Reagents: Scope and Limitations
Nosik, Pavel S.,Pashko, Mykola O.,Poturai, Andrii S.,Kvasha, Denys A.,Pashenko, Alexander E.,Rozhenko, Alexander B.,Suikov, Sergiy,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Yagupolskii, Yurii L.
, p. 6604 - 6615 (2021/12/08)
A general approach to gem-difluorocyclopropenes synthesis based on the reaction of alkynes with Ruppert-Prakash reagent is reported. The proposed method is evaluated for the synthesis of a wide difluorocyclopropenes scope based on their bench lifespan and hydrolytic stability. The tolerance of the method for common functional groups was shown. Previously unavailable difluorocyclopropenes substituted with aliphatic were prepared using the proposed procedure. The retain of stability was proven by the multigram scale synthesis and further storage in the temperature interval ?78 to ?4 °C over a year. This makes them attractive building blocks and intermediates for organic synthesis. The reasons for dropping stability were defined. The relations between the structure of the substituents and the stability of the difluorocyclopropene ring were determined and discussed.
GENERAL SYNTHESIS OF CYCLOPROPENONES AND THEIR ACETALS
Isaka, Masahiko,Ejiri, Satoshi,Nakamura, Eiichi
, p. 2045 - 2058 (2007/10/02)
Metalated cyclopropenone acetals 5 react with a variety of electrophiles, including alkyl halides, carbonyl compounds, vinyl iodides, vinyl triflates, and aryl iodides, to give substituted cyclopropenone acetals in high yield.Hydrolysis of the acetal unde
