1227636-85-2Relevant academic research and scientific papers
Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases
Best, Daniel,Chairatana, Phoom,Glawar, Andreas F.G.,Crabtree, Elizabeth,Butters, Terry D.,Wilson, Francis X.,Yu, Chu-Yi,Wang, Wu-Bao,Jia, Yue-Mei,Adachi, Isao,Kato, Atsushi,Fleet, George W.J.
, p. 2222 - 2224 (2010)
2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer l-DGJNAc is a very weak but non-competitive-inhibitor of β-hexosaminidases.
