1227692-48-9Relevant academic research and scientific papers
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis
Chen, Tian,Benmohamed, Radhia,Arvanites, Anthony C.,Ranaivo, Hantamalala Ralay,Morimoto, Richard I.,Ferrante, Robert J.,Watterson, D. Martin,Kirsch, Donald R.,Silverman, Richard B.
experimental part, p. 613 - 622 (2011/03/17)
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assa
