1227692-75-2Relevant academic research and scientific papers
ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: Potential application for the treatment of amyotrophic lateral sclerosis
Chen, Tian,Benmohamed, Radhia,Kim, Jinho,Smith, Karen,Amante, Daniel,Morimoto, Richard I.,Kirsch, Donald R.,Ferrante, Robert J.,Silverman, Richard B.
experimental part, p. 515 - 527 (2012/03/26)
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. The arylsulfanyl pyrazolone (ASP) scaffold was one of the active scaffolds identified in a cell-based high throughput screening assay targeting mutant Cu/
