1227700-47-1

Basic information

• Product Name: 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione
• Synonyms: 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione
• CAS NO: 1227700-47-1
• Molecular Weight: 302.018
• Mol File: 1227700-47-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 207-212°C
• CAS DataBase Reference: 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione(1227700-47-1)
• EPA Substance Registry System: 6-methyl-2-[5-trifluoromethyl]-2-pyridyl-1,3,6,2-dioxazaborocane-4,8-dione(1227700-47-1)

Safety Data

• Hazardous Substances Data: 1227700-47-1(Hazardous Substances Data)

Usage

Uses

2-Pyridyl substituted MIDA boronate is one of several offerings that overcome several problems other 2-pyridyl substituted boronates have, e.g. protodeborylation, long-term storage, insufficient reactivity with aryl chlorides.

Upstream product

• 5419-55-6 Triisopropyl borate 
• 4408-64-4 N-methyliminodiacetic acid 
• 50488-42-1 2-bromo-5-(trifluoromethyl)pyridine 

Downstream Products

• 296776-84-6 2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine 

Relevant articles and documents

HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.

General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates

A wide range of 2-pyridyl and other difficult-to-access heterocyclic N-methyliminodiacetic acid boronates can be readily prepared from the corresponding bromides via a new method involving direct transligation of 2-heterocyclic trialkoxyborate salts with N-methyliminodiacetic acid (MIDA) at elevated temperatures.