1227703-50-5Relevant articles and documents
Unraveling the C2-Symmetric Azatetraquinane System. Simple, Enantioselective Syntheses
Reddy, G. Sudhakar,Reddy, D. Srinivas,Corey
, p. 2258 - 2262 (2021/04/05)
Concise stereocontrolled synthetic routes to the C2-symmetric azatetraquinane 1 (or, also, the enantiomer) are described. The successful execution of the synthesis involved innovation in the methodology for [3+2] cycloaddition and stereochemical control.
An Improved and Enantioselective Preparation of the Telaprevir Bicyclic [3.3.0] Proline Intermediate and Reuse of Unwanted Enantiomer
Liu, Lin-Wei,Wang, Fei-Ying,Tian, Fang,Peng, Lin,Wang, Li-Xin
, p. 320 - 324 (2016/03/04)
An improved, concise, and efficient preparation of the telaprevir bicyclic [3.3.0] proline intermediate is presented. The key steps, control points, and the whole process are optimized. The synthesis of racemic intermediate was accomplished in five steps
PROCESS FOR PRODUCING ESTER COMPOUND
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Paragraph 0143-0146, (2014/04/17)
Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.
