122772-23-0

Basic information

• Product Name: 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• Synonyms: 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
• CAS NO: 122772-23-0
• Molecular Formula: C₁₇H₁₇N₃O₃S
• Molecular Weight: 343.40018
• Mol File: 122772-23-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(122772-23-0)
• EPA Substance Registry System: 5-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione(122772-23-0)

Safety Data

• Hazardous Substances Data: 122772-23-0(Hazardous Substances Data)

Upstream product

• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 104-94-9 4-methoxy-aniline 
• 93-07-2 Veratric acid 
• 122772-04-7 1-(3,4-dimethoxybenzoyl)-4-(4-methoxyphenyl)thiosemicarbazide 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 41764-74-3 3,4-dimethoxybenzohydrazide 

Relevant articles and documents

Synthesis, acetylcholinesterase and alkaline phosphatase inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives

A new series of 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones (6as) and 2,5-disubstituted-1,3,4-thiadiazoles (7ah) was synthesized by intramolecular dehydrocyclization of various 1,4-disubstituted thiosemicarbazide derivatives (5as) by refluxing in 4N aqueous sodium hydroxide and by overnight stirring with polyphosphoric acid, respectively. The structures of these compounds were characterized by IR, 1H and 13C NMR, elemental analysis and mass spectroscopic studies. All the synthesized compounds were screened for their acetylcholinesterase and alkaline phosphatase inhibition studies. Most of the tested compounds showed promising activities, amongst them (6k) and (6q) showed excellent acetylcholinesterase inhibitory activity with IC50 0.2410.012 and 0.2600.013M, respectively, as compared with those of standard drug whereas the compound (6p), with IC50 0.0440.001M, was found to be the most potent inhibitor of alkaline phosphatase.