1227779-97-6

Basic information

• Product Name: 3-(4-((7-(3-tert-butylureido)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-ylamino)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid
• Synonyms: 3-(4-((7-(3-tert-butylureido)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-ylamino)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid
• CAS NO: 1227779-97-6
• Molecular Weight: 549.589
• Mol File: 1227779-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-((7-(3-tert-butylureido)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-ylamino)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-((7-(3-tert-butylureido)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-ylamino)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid(1227779-97-6)
• EPA Substance Registry System: 3-(4-((7-(3-tert-butylureido)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-ylamino)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid(1227779-97-6)

Safety Data

• Hazardous Substances Data: 1227779-97-6(Hazardous Substances Data)

Upstream product

• 18523-47-2 3-azidopropanoic acid 
• 1227779-95-4 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(prop-2-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 

Relevant articles and documents

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

A library of pyrido[2,3-d]pyrimidines was designed as inhibitors of FGFR3 tyrosine kinase allowing possible interactions with an unexploited region of the ATP binding-site. This library was built-up with an efficient step of click-chemistry giving easy access to triazole-based compounds bearing a large panel of substituents. Among the 27 analogues synthesized, more than half exhibited 55-89% inhibition of in vitro FGFR3 kinase activity at 2 μM and one (19g) was able to inhibit auto-phosphorylation of mutant FGFR3-K650M in transfected HEK cells.